| 1 | Sat 14 Aug 2021 | 251-1 v Bayer 04 Leverkusen1. FC Union Berlin 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Thu 26 Aug 2021 | 250-0 v KuPS Kuopio1. FC Union Berlin 0-0 KuPS Kuopio | UEFA Europa Conference League |
| 3 | Sun 29 Aug 2021 | 252-1 v Borussia Mönchengladbach1. FC Union Berlin 2-1 Borussia Mönchengladbach | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 250-0 v FC Augsburg1. FC Union Berlin 0-0 FC Augsburg | German Bundesliga |
| 5 | Sun 19 Sep 2021 | 252-4 v Borussia DortmundBorussia Dortmund 4-2 1. FC Union Berlin | German Bundesliga |
| 6 | Sat 25 Sep 2021 | 251-0 v Arminia Bielefeld1. FC Union Berlin 1-0 Arminia Bielefeld | German Bundesliga |
| 7 | Thu 21 Oct 2021 | 251-3 v FeyenoordFeyenoord 3-1 1. FC Union Berlin | UEFA Europa Conference League |
| 8 | Sun 24 Oct 2021 | 251-1 v VfB StuttgartVfB Stuttgart 1-1 1. FC Union Berlin | German Bundesliga |
| 9 | Sat 30 Oct 2021 | 252-5 v Bayern Munich1. FC Union Berlin 2-5 Bayern Munich | German Bundesliga |
| 10 | Sun 7 Nov 2021 | 25 2-2 v 1. FC Köln1. FC Köln 2-2 1. FC Union Berlin | German Bundesliga |
| 11 | Sat 20 Nov 2021 | 252-0 v Hertha Berlin1. FC Union Berlin 2-0 Hertha Berlin | German Bundesliga |
| 12 | Thu 25 Nov 2021 | 25 1-0 v Maccabi HaifaMaccabi Haifa 0-1 1. FC Union Berlin | UEFA Europa Conference League |
| 13 | Sun 28 Nov 2021 | 251-2 v Eintracht FrankfurtEintracht Frankfurt 2-1 1. FC Union Berlin | German Bundesliga |
| 14 | Fri 3 Dec 2021 | 252-1 v RB Leipzig1. FC Union Berlin 2-1 RB Leipzig | German Bundesliga |
| 15 | Thu 9 Dec 2021 | 251-1 v Slavia Prague1. FC Union Berlin 1-1 Slavia Prague | UEFA Europa Conference League |
| 16 | Sun 12 Dec 2021 | 250-1 v Greuther FürthGreuther Fürth 1-0 1. FC Union Berlin | German Bundesliga |
| 17 | Wed 15 Dec 2021 | 250-0 v SC Freiburg1. FC Union Berlin 0-0 SC Freiburg | German Bundesliga |
| 18 | Sat 15 Jan 2022 | 252-1 v 1899 Hoffenheim1. FC Union Berlin 2-1 1899 Hoffenheim | German Bundesliga |
| 19 | Sat 22 Jan 2022 | 252-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 1. FC Union Berlin | German Bundesliga |
| 20 | Sat 5 Feb 2022 | 250-2 v FC AugsburgFC Augsburg 2-0 1. FC Union Berlin | German Bundesliga |
| 21 | Sun 13 Feb 2022 | 25 0-3 v Borussia Dortmund1. FC Union Berlin 0-3 Borussia Dortmund | German Bundesliga |
| 22 | Sat 19 Feb 2022 | 250-1 v Arminia BielefeldArminia Bielefeld 1-0 1. FC Union Berlin | German Bundesliga |
| 23 | Sat 26 Feb 2022 | 25 3-1 v Mainz 051. FC Union Berlin 3-1 Mainz 05 | German Bundesliga |
| 24 | Sat 5 Mar 2022 | 250-1 v VfL WolfsburgVfL Wolfsburg 1-0 1. FC Union Berlin | German Bundesliga |
| 25 | Sat 12 Mar 2022 | 251-1 v VfB Stuttgart1. FC Union Berlin 1-1 VfB Stuttgart | German Bundesliga |
| 26 | Sat 19 Mar 2022 | 25 0-4 v Bayern MunichBayern Munich 4-0 1. FC Union Berlin | German Bundesliga |
| 27 | Fri 1 Apr 2022 | 251-0 v 1. FC Köln1. FC Union Berlin 1-0 1. FC Köln | German Bundesliga |
| 28 | Sat 9 Apr 2022 | 254-1 v Hertha BerlinHertha Berlin 1-4 1. FC Union Berlin | German Bundesliga |
| 29 | Sun 17 Apr 2022 | 25 2-0 v Eintracht Frankfurt1. FC Union Berlin 2-0 Eintracht Frankfurt | German Bundesliga |